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Kaur, B.
- Mass Jatropha Plant Seed Poisoning Profile and Clinical Outcome of Cases
Authors
1 Department of Paediatrics, Government Medical College & Rajindra Hospital, Patiala, Punjab, IN
Source
The Indian Practitioner, Vol 67, No 3 (2014), Pagination: 158-160Abstract
Introduction: Despite lot of parental care & disciplined care at schools, accidental poisoning is not an uncommon presentation in paediatric emergency.
Objective: Case Report is aimed to describe clinical profile and outcome of children admitted for acute jatropha poisoning at community health centre (CHC) in District Fatehgarh sahib, Punjab.
Material & Methods: Children admitted to CHC for acute Jatropha plant seed poisoning were subjects of study. Chief complaints, history, clinical presentation, laboratory findings and treatment modality and outcome of patients and duration of treatment were recorded on CHC charts, mean, summation, percentage & frequency distribution were used where applicable.
Result: 36 children reported in study belonged to local primary school age ranging from 6-12 years. Most prominent symptom of poisoning is nausea, vomiting, abdominal pain and most serious sequel hypovolaemic shock.
Conclusion: Jatropha plant seed poisoning manifests as gastrointestinal symptoms. Cornerstone of treatment is decontamination and hydration.
Keywords
Jatropha, Physic Nut, Ratanjot, Poisoning.
- Cardiodepressant Activity of Newer Dihydropyrimidine Derivative in Comparison to Nifedipine on Perfused Rabbits Heart
Authors
1 Department of Pharmacology, Punjab Institute of Medical Sciences (PIMS), Jalandhar, Punjab, IN
2 GMC, Patiala, Punjab, IN
3 Punjabi University, Patiala, Punjab, IN
4 Genesis Institute of Dental Sciences & Research, Ferozepur, Punjab, IN
Source
International Journal of Medical and Dental Sciences, Vol 1, No 2 (2012), Pagination: 6-14Abstract
Background: Substituted dihydropyridine calcium channel blockers are used in the treatment of cardiovascular diseases. Dihydropyridines are considered as analogue of dihydropyrimidines.
Objectives: In present study newly synthesized test compound 5- Acyl-6-methyl-4(2',3'-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4- dihydropyrimidine, a dihydropyrimidine derivative was investigated with an aim to get valuable substitute for the well known dihydropyridine, Nifedipine.
Material & Methods: The Calcium Channel blocking actiuity of test compound was studied on Rabbit's Heart and its effects were compared with Nifedipine used as control.
Results: Test compound has dose-dependent negative chronotropic and negative inotropic effect on Rabbit's heart but these effects appeared at doses higher than those of Nifedipine. Test compound had no significant change in coronary flow however Nifedipine show significant increase in coronary flow at lower doses.
Conclusion: Test compound appears to be less potent myocardial depressant compared to Nifedipine. Test compound produced calcium channel blocking activity which was dose related and in order to ascertain the status of this compound as a drug, further studies are needed not only in other animals and tissue models but also in various pathophysiological models.
Keywords
Test Compound (5-Acyl-6-Methyl-4(2’,3’-Methylenedioxy) Phenyl - 2 - S - Ethyl - 1, 4-Dihydropyrimidine), DMSO (Dimethylsulphoxide), Nifedipine.Full Text
